A new absorption ratio method was developed and validated for the determination of Paracetamol and pamabrom in Bulk and binary mixture. The method involved Q-absorption analysis based on the measurement of absorbance at two wavelengths, i.e λmax of Pamabrom (279.0 nm) and Iso-absorptive point of both drugs (265.0 nm). Beer’s law was obeyed in the concentration range between 4-14 μg/ml for Paracetamol and 2-12 μg/ml for Pamabrom. The results of analysis have been validated statistically and by recovery studies. The method was found to be simple, precise, reproducible, less time consuming and economical. Hence it is more suitable for routine analysis of these drugs in combined dosage forms.
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